Bioactive Small Molecules
Medchemexpress LLC CCT241533 hydrochloride | 1431697-96-9 | 98.55% | 478.94 | 100 MG
CCT241533 hydrochloride is a potent and selective CHK2 inhibitor, demonstrating an IC50 of 3 nM and a Ki of 1.16 nM. It effectively inhibits CHK2 activity in human tumor cell lines when responding to DNA damage and significantly potentiates the cytotoxicity of PARP inhibitors.
- Potent and selective CHK2 inhibitor with IC50 of 3 nM and Ki of 1.16 nM.
- Inhibits CHK2 activity in human tumor cell lines in response to DNA damage.
- Significantly potentiates the cytotoxicity of PARP inhibitors.
- Demonstrates 63-fold selectivity over CHK1 (IC50=190 nM).
- Exhibits low hERG inhibition (IC50=22 μM).
- Blocks CHK2 autophosphorylation at S516.
- Abolishes induction of pS516 CHK2 signal with PARP inhibitor alone.
- Shows cytotoxicity in HT-29, HeLa, and MCF-7 cells.
Medchemexpress LLC JAK1-IN-4 25mg | 2091134-35-7 | 521.59 | C26H32FN9O2 | 25 MG
JAK1-IN-4 is a potent, selective small-molecule inhibitor of Janus kinase 1 used in preclinical research to probe JAK/STAT signaling.
- Potent JAK1 inhibition, biochemical IC50 85 nM.
- High selectivity versus JAK2 and JAK3 (IC50 12.8 μM and >30 μM).
- Cellular activity inhibits STAT3 phosphorylation in NCI-H1975 cells (IC50 227 nM).
- High chemical purity, 99.26%.
- Soluble in DMSO at 100 mg/mL (requires sonication).
- Molecular formula C26H32FN9O2; molecular weight 521.59 g/mol.
Selleck Chemical LLC BMS-986020 S3572-25mg
BMS-986020 (AM152 AP-3152 free acid) is a potent and selective antagonist of lysophosphatidic acid receptor 1 (LPA1) BMS-986020 inhibits bile acid and phospholipid transporters with IC50 of 4 8 M 6 2 M and 7 5 M for BSEP MRP4 and MDR3 respectively BMS-986020 has the potential for the treatment of idiopathic pulmonary fibrosis (IPF)
Medchemexpress LLC (±)-Boc-α-phosphonoglycine trimethyl ester | 89524-98-1 | MFCD02178893 | 297.24 | 10 G
(±)-Boc-α-phosphonoglycine trimethyl ester (MedChemExpress HY-W008206) is a chemical compound used as a glycine equivalent and glycine donor in organic synthesis. It has strong α-proton acidity and its reaction byproducts are water-soluble and easy to purify.
- Functions as a glycine equivalent and glycine donor
- Strong α-proton acidity
- Reaction byproducts are water-soluble and easy to purify
- Efficiently yields target 5,6- and 5,8-dimethoxy-substituted ester products
- Used in four mild reactions
- For research use only
Medchemexpress LLC Budipine | 57982-78-2 | 293.45 | 5 MG
Budipine is an anti-parkinson agent that functions as a substrate of P-glycoprotein (P-gp), mediating its uptake into the brain. It also acts as an N-methyl-d-aspartate (NMDA) antagonist and exhibits indirect dopaminergic effects by improving dopamine release and inhibiting monoamine oxidase type B (MAO-B). Budipine is suitable for research on central nervous system (CNS) disorders, including Parkinson's disease.
- P-glycoprotein (P-gp) substrate
- N-methyl-d-aspartate (NMDA) antagonist
- Improves dopamine release
- Inhibits monoamine oxidase type B (MAO-B)
- Used in research for CNS disorders, including Parkinson's disease
Cayman Chemical Bufexamac, Purity: ≥98%, CAS: 2438-72-4, 100 mg
An NSAID and a class IIb HDAC inhibitor; inhibits IFN-α production in PBMCs (EC50 = 8.9 µM); induces hyperacetylation of tubulin (IC50 = 2.9 µM); inhibits LTA4 hydrolase and aminopeptidase activity (IC50s = 15.86 and 11.59 µM, respectively); inhibits 5-LO (IC50 = 27 µM); inhibits the production of LTB4 in neutrophils (IC50 = 12.91 µM) and reduces fMLP-induced neutrophil migration at 50 and 100 µM; reduces neutrophil levels, as well as TNF-α and IL-1β protein levels, in BALF in a mouse model of LPS-induced acute lung injury at 100 mg/kg
Cayman Chemical CM-272, Purity: ≥95%, CAS: 1846570-31-7, 1 mg
An inhibitor of G9a, GLP, and DNA methyltransferases (IC50s = 8, 2, 382, 85, and 1,200 nM for G9a, GLP, DNMT1, DNMT3A, and DNMT3B, respectively); inhibits the growth of, and induces apoptosis in, hematological cancer cell lines (GI50s = 218-455 nM); induces the expression of IFN-stimulated genes and immunologic cell death markers in hematological cancer cell lines; reduces tumor growth in MV4-11 and EGI-1 mouse xenograft models at 2.5 mg/kg; increases survival in CEMO-1 and RT112 mouse xenograft models at 2.5 and 5 mg/kg, respectively
Medchemexpress LLC HY-14855 5mg , Tedizolid CAS:856866-72-3 Purity:>98%
HY-14855 5mg Tedizolid CAS: 856866-72-3 Tedizolid (TR 700; Torezolid; DA-7157) is a novel oxazolidinone, acting through inhibition of bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA) of the 50S subunit of the ribosome. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC (S)-1-(6-(4-fluoro-1H-pyrazol-1-yl)pyridin-3-yl)ethanamine dihydrochloride | 1980023-97-9 | 98.3% | 279.15 | C10H13Cl2FN4 | 100 MG
(S)-1-(6-(4-fluoro-1H-pyrazol-1-yl)pyridin-3-yl)ethanamine dihydrochloride is a chiral drug intermediate used in the synthesis of active pharmaceutical compounds.
- Chiral dihydrochloride salt suitable for synthetic applications.
- High purity (98.3%) for research use.
- Molecular formula C10H13Cl2FN4 and molecular weight 279.15.
- Available in milligram- to gram-scale pack sizes for development and scale-up.
Cayman Chemical Danicopan, Purity: ≥98%, CAS: 1903768-17-1, 10 mg
A Factor D inhibitor (IC50 = 15 nM in a cell-free assay); selective for Factor D over a panel of 12 serine proteases when used at a concentration of 10 µM; inhibits hemolysis of erythrocytes isolated from patients with paroxysmal nocturnal hemoglobinuria (IC50s = 4-27 nM); suppresses APC activity in monkeys at 200 mg/kg, p.o.
Cayman Chemical ICA 121431, Purity: ≥98%, CAS: 313254-51-2, 5 mg
A selective Nav1.1 and Nav1.3 channel blocker (IC50s = 10,000 nM for Nav1.1, Nav1.3, Nav1.4, and Nav1.5-1.8, respectively); induces a concentration-dependent hyperpolarizing shift in voltage dependence of inactivation of Nav1.3 channels at 1 μM; substitution of the Nav1.3 VSD4 with the Nav1.5 VSD4 reduces potency by ~500-fold
Lkt Laboratories R,S-Sulforaphane, ≥99%, 100MG
Phase II enzyme inducer; Nrf2 activator; antioxidant with anticarcinogenic properties. CAS: 4478-93-7. Additional sizes available upon request. Ships from Saint Paul, MN.
Medchemexpress LLC Chloroquine dihydrochloride | 3545-67-3 | 99.6% | 1 ML
Chloroquine dihydrochloride is an antimalarial and anti-inflammatory agent. It is widely used to treat malaria and rheumatoid arthritis, and functions as an autophagy and toll-like receptors (TLRs) inhibitor. This product has shown high effectiveness in controlling SARS-CoV-2 (COVID-19) infection in vitro.
- Antimalarial and anti-inflammatory agent
- Used to treat malaria and rheumatoid arthritis
- Autophagy and toll-like receptors (TLRs) inhibitor
- Effective in controlling SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)
- For research use only
Medchemexpress LLC Glurate (4-acetylbutyric acid) | 3128-06-1 | MFCD00004412 | 130.14 | 10 G
Glurate (4-acetylbutyric acid) is an acylating agent used in the development of antiviral compounds. It targets retroviruses such as herpes virus and HIV, and can also be used in the synthesis of acyclic nucleoside derivatives and 5-hydroxyhexanoic acid.
- Acylating agent
- Used in development of antiviral compounds
- Targets retroviruses (herpes virus and HIV)
- Synthesis of acyclic nucleoside derivatives
- Synthesis of 5-hydroxyhexanoic acid
Medchemexpress LLC Dopamine Receptor D3 Antibody (YA1742) | 50 UL
Dopamine Receptor D3 Antibody (YA1742) is a rabbit-derived and non-conjugated IgG monoclonal antibody targeting Dopamine Receptor D3. It is reactive with human, mouse, and rat species, making it suitable for various research applications, particularly Western Blot (WB). The antibody is supplied as a liquid formulation containing rabbit IgG in 10mM phosphate-buffered saline, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide, and 50% glycerol.
- Targets dopamine receptor D3
- Reactive with human, mouse, and rat species
- Non-conjugated IgG monoclonal antibody
- Application in Western blot (WB) with a dilution ratio of 1:500-1:1000
- Predicted and observed band size of 44 kDa
- Stored at -20°C for 1 year
- Avoid repeated freeze/thaw cycles